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- Title
The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy.
- Authors
Wang, Bo; Wang, Liping; Peng, Ying; Pang, Yiying; Xiao, Hesheng; Wang, Xiaoji; Huang, Shuangping; Díez, David; Castro, María Ángeles
- Abstract
Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner–Wadsworth–Emmons reaction and the protection of multiple hydroxyls using silyl protecting groups. The employment of the readily removable silyl protecting groups allows the synthesis of (±)-methyl salvianolate A and its derivatives on a reasonably large scale.
- Subjects
CHEMICAL synthesis; HYDROXYL group; CHEMICAL reactions; SILYL group; NATURAL products
- Publication
Molecules, 2019, Vol 24, Issue 5, p999
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24050999