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- Title
Improved Antioxidant Capacity of Optimization of a Self-Microemulsifying Drug Delivery System for Resveratrol.
- Authors
Ying Chen; Huiyong Zhang; Jing Yang; Haiyan Sun
- Abstract
The use of nano-encapsulated resveratrol (RSV) in self-micro-emulsified drug delivery systems (SMEDDS) formulations was investigated. Self-emulsifying grading tests were used to establish the optimal ratio of oil, surfactant, and co-surfactant. The optimized system was further investigated for the droplet size and zeta potential at the different medium pH values by a Malvern Zetasizer and transmission electron microscopy (TEM). The antioxidant capacity and cytotoxicity of the formulation were detected by DCFH-DA and a CCK-8 assays. The results showed that the nano-emulsion based on ethyl oleate, Tween-80, and PEG-400 (35:40:25, w/w/w) was the most stable formulation due to the small droplet size (approximately 50 nm) and high zeta potential in a neutral environment. Furthermore, this formulation also exhibited a greater antioxidant capacity with less toxicity than free RSV. Taken together, considering these results and the simple fabrication process, this formulation could be used to deliver nutritional food supplements in a stable, efficient, and safe manner.
- Subjects
RESVERATROL; DRUG delivery systems; SURFACE active agents; TRANSMISSION electron microscopy; OLEATES; CARDIOVASCULAR disease treatment
- Publication
Molecules, 2015, Vol 20, Issue 12, p21167
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules201219750