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- Title
Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells.
- Authors
You Ah Kim; Chang-Suk Kong; Hyo Hyun Park; Eunkyung Lee; Mi-Soon Jang; Ki-Ho Nam; Youngwan Seo
- Abstract
The inhibitory effect of three chromones 1–3 and two coumarins 4–5 on the production of nitric oxide (NO) was evaluated in LPS-induced RAW 264.7 macrophage cells. Among the compounds tested heterocarpin (1), a furochromone, significantly inhibited its production in a dose-dependent manner. In addition, heterocarpin suppressed prostaglandin E2 (PGE2) production and expression of cytokines such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6).
- Subjects
INFLAMMATION treatment; SALT marsh plants; CORYDALIS; PROTEIN expression; CYTOKINES; CYCLOOXYGENASE 2 inhibitors
- Publication
Molecules, 2015, Vol 20, Issue 8, p14474
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules200814474