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- Title
A Tractable and Efficient One-Pot Synthesis of 5'-Azido-5'-deoxyribonucleosides.
- Authors
Peterson, Theodore V.; Streamland, Tobin U. B.; Awad, Ahmed M.
- Abstract
Synthetic routes to 5'-azidoribonucleosides are reported for adenosine, cytidine, guanosine, and uridine, resulting in a widely applicable one-pot methodology for the synthesis of these and related compounds. The target compounds are appropriate as precursors in a variety of purposive syntheses, as the synthetic and therapeutic relevance of azido- and amino-modified nucleosides is expansive. Furthermore, in the conversion of alcohols to azides, these methods offer a tractable alternative to the Mitsunobu and other more difficult reactions.
- Subjects
RIBONUCLEOSIDES; ADENOSINES; GUANOSINE; URIDINE; NUCLEOTIDES; ALCOHOLS (Chemical class)
- Publication
Molecules, 2014, Vol 19, Issue 2, p2434
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules19022434