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- Title
Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents.
- Authors
Shang-Shing P. Chou; Jui-Chi Juan; Shwu-Chen Tsay; Kuei Pin Huang; Jih Ru Hwu
- Abstract
Two series of oxime esters containing the 2,6-diazaanthracene-9,10-dione bis-(O-benzoyloxime) and 4,5-diazafluoren-9-one O-9-benzoyloxime moieties have been synthesized and tested as photo-induced DNA cleaving agents. All these compounds were found to cleave DNA upon irradiation with 312 nm UV light. The structure-activity relationship of these molecules for DNA cleavage was established. A plausible reaction mechanism is also proposed.
- Subjects
OXIMES; ORGANONITROGEN compounds; ESTERS; MOIETIES (Chemistry); IRRADIATION; DNA
- Publication
Molecules, 2012, Vol 17, Issue 3, p3370
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules17033370