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- Title
Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis.
- Authors
Min Xu; Litaudon, Marc; Krief, Sabrina; Martin, Marie-Thérèse; Kasenene, John; Kiremire, Bernard; Dumontet, Vincent; Guéritte, Françoise
- Abstract
One new drimane-type sesquiterpenoid, named ugandenial A (1), was isolated from the ethyl acetate extract of the bark of Warburgia ugandensis (Canellaceae) together with eight known drimane-type sesquiterpenoids: 11α-hydroxycinnamosmolide (2), warburganal (3), polygodial (4), mukaadial (5), dendocarbin A (6), 9α-hydroxycinnamolide (7), dendocarbin L (8) and dendocarbin M (9). Their structures were established by detailed spectroscopic analysis. In addition a keto-enol equilibrium was demonstrated for compound 1 through a detailed NMR analysis run in CD2Cl2 at 190 K. Cytotoxicity of the isolated compounds against KB cells was evaluated.
- Subjects
SESQUITERPENES; PLANT extracts; BARK; ACETATES; SPECTRUM analysis; NUCLEAR magnetic resonance; CHROMATOGRAPHIC analysis; CHIMPANZEES as laboratory animals; CELL-mediated cytotoxicity; CELL lines; PLANT toxins
- Publication
Molecules, 2009, Vol 14, Issue 10, p3844
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules14103844