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- Title
Factors affecting the live-birth rate in women with diminished ovarian reserve undergoing IVF-ET.
- Authors
Huang, Yun; Li, Jingyi; Zhang, Fang; Liu, Yifeng; Xu, Gufeng; Guo, Jing; Zhang, Runjv; Wu, Yiqing; Liu, Juan; Chen, Kai; Zhao, Wei; Wu, Wei; Hu, Yanjun; Chen, Guangdi; Zhang, Dan
- Abstract
<bold>Purpose: </bold>The occurrence of diminished ovarian reserve (DOR) in women was growing in recent years. Although in vitro fertilization and embryo transfer (IVF-ET) became an effective treatment for DOR, the live-birth (LB) rate remains unsatisfactory. This study aimed to investigate the impact factors of LB rate in women with DOR undergoing assisted reproduction.<bold>Methods: </bold>This was a single-center retrospective cohort study. A total of 2277 IVF-ET or ICSI cycles from 1957 DOR women were analysed. Impact factors of LB rate were explored via Student's t test, Pearson's Chi-square test, and multivariate logistic regression models.<bold>Results: </bold>There were statistically significant differences in maternal age (P < 0.001), duration of infertility (P < 0.001), female body mass index (P = 0.039), first IVF cycle (P = 0.004), poor ovarian response (P < 0.001), paternal age (P < 0.001), total gonadotropin dose (P = 0.010), endometrial thickness (P = 0.021), number of follicles ≥ 14 mm (P = 0.007), number of oocytes retrieved (P < 0.001), number of frozen embryos (P = 0.014), and the stage (P < 0.001) and number (P < 0.001) of embryos transferred between the non-live-birth (NLB) and LB groups. However, only factors of maternal age, the stage and number of embryos transferred remained different after adjusting for potential confounders.<bold>Conclusions: </bold>Maternal age, the stage and number of embryos transferred were independent impact factors affecting the live-birth rate in women with DOR seeking for assisted conception.
- Subjects
OVARIAN reserve; FERTILIZATION (Biology); HUMAN artificial insemination; BODY mass index; HUMAN fertility; INFERTILITY treatment; RESEARCH; BIRTH rate; RESEARCH methodology; SPERM motility; RETROSPECTIVE studies; EVALUATION research; MEDICAL cooperation; PREGNANCY outcomes; EMBRYO transfer; COMPARATIVE studies; MATERNAL age; OVARIAN diseases; RESEARCH funding; FERTILIZATION in vitro; INDUCED ovulation; LONGITUDINAL method
- Publication
Archives of Gynecology & Obstetrics, 2018, Vol 298, Issue 5, p1017
- ISSN
0932-0067
- Publication type
journal article
- DOI
10.1007/s00404-018-4884-4