We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The complete genome sequence analysis of West Nile virus strains isolated in Slovakia (central Europe).
- Authors
Drzewnioková, Petra; Barzon, Luisa; Franchin, Elisa; Lavezzo, Enrico; Bakonyi, Tamás; Pistl, Juraj; Csank, Tomáš
- Abstract
The present study reports the first complete genome sequence analysis of West Nile virus (WNV) strains isolated from brain samples from raptors. The results prove the circulation of closely related WNV lineage II strains in central Europe and genetic analysis revealed seven amino acid substitutions in structural (PrM3, E159 and E231) and in non-structural (NS1109, NS5259, NS5310 and NS5600) proteins. Observed amino acid substitutions Phe3 and Ser231 were common only within the lineage VII Koutango strain isolated from Rhipicephalus guilhoni tick in Senegal. Further research could reveal whether these substitutions influence the biological properties of WNV, including virulence and neuroinvasiveness.
- Subjects
NUCLEOTIDE sequencing; WEST Nile virus; BIRDS of prey; AMINO acids; RHIPICEPHALUS; MICROBIAL virulence
- Publication
Archives of Virology, 2019, Vol 164, Issue 1, p273
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-018-4056-7