We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
GBV-C/HIV-1 coinfection is associated with low HIV-1 viral load and high CD4 T lymphocyte count.
- Authors
Miranda, Bárbara; Sá, Keyla; Silva, Andrea; Feitosa, Rosimar; Cayres-Vallinoto, Izaura; Ishak, Ricardo; Vallinoto, Antonio
- Abstract
GB virus C (GBV-C) is a lymphotropic virus with a low level or non-existent replication in the liver. The interaction between HIV-1 and GBV-C apparently reduces the progression of HIV-1 infection to AIDS and improves the quality of life of HIV-1 infected individuals. A cross-sectional study was established to determine the possible effect of HIV-1/GBV-C coinfection on HIV-1 viral load and CD4 T lymphocyte counts. Samples from 313 HIV-1 infected persons from the Virus Laboratory of the Federal University of Pará as well as demographic and clinical information were obtained from medical records. This study used a nested PCR method to determine GBV-C viremia. The prevalence of HIV-1/GBV-C coinfection was 17%. There were no significant differences in the distribution according to age, sex or ethnicity between the groups. The differences in HIV-1 viral load and CD4 T lymphocyte count between the HIV-1 and HIV-1/GBV-C groups were highly significant, indicating that coinfection results in lower viral loads and higher CD4 T lymphocyte counts compared to HIV-1 mono-infection. The results indicate a protective effect among coinfected individuals.
- Subjects
MIXED infections; VIRAL load; CD4 lymphocyte count; HIV; HIV infections; DISEASE prevalence
- Publication
Archives of Virology, 2017, Vol 162, Issue 11, p3431
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-017-3514-y