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- Title
CD16 natural killer cells play a limited role against primary dengue virus infection in tamarins.
- Authors
Yoshida, Tomoyuki; Omatsu, Tsutomu; Saito, Akatsuki; Katakai, Yuko; Iwasaki, Yuki; Iijima, Sayuki; Kurosawa, Terue; Hamano, Masataka; Nakamura, Shinichiro; Takasaki, Tomohiko; Yasutomi, Yasuhiro; Kurane, Ichiro; Akari, Hirofumi
- Abstract
CD16 is a major molecule expressed on NK cells. To directly assess the role of natural killer (NK) cells in dengue virus (DENV) infection in vivo, CD16 antibody-treated tamarins were inoculated with a DENV-2 strain. This resulted in the transient depletion of CD16 NK cells, whereas no significant effects on the overall levels or kinetics of plasma viral loads and antiviral antibodies were observed in the treated monkeys when compared to control monkeys. It remains elusive whether the CD16 NK subpopulation could play an important role in the control of primary DENV infection.
- Subjects
KILLER cells; DENGUE viruses; VIRUS diseases; TAMARINS; VIRAL load; IMMUNOGLOBULINS; ANTIVIRAL agents
- Publication
Archives of Virology, 2012, Vol 157, Issue 2, p363
- ISSN
0304-8608
- Publication type
Report
- DOI
10.1007/s00705-011-1178-6