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- Title
Effect of Corticosteroids on Facial Function after Cerebellopontine Angle Tumor Removal: A Double-Blind Study versus Placebo.
- Authors
Bozorg Grayeli, alexis; Ferrary, Evelyne; Tubach, Florence; Bernat, Isabelle; Deguine, Olivier; Darrouzet, Vincent; Robier, alain; Zaouche, Sandra; Dubreuil, Christian; Marx, Mathieu; Kalamarides, Michel; Fraysse, Bernard; Sterkers, Olivier
- Abstract
The aim of this study was to assess the effect of corticosteroids administered intra- and postoperatively on the occurrence of facial palsy after a cerebellopontine angle (CPA) tumor resection, and to investigate pre- and intraoperative prognostic factors. A multicenter, prospective, randomized, double-blind and versus-placebo study was conducted between 2006 and 2010. Three hundred and ten patients operated on for a CPA tumor (96% vestibular schwannomas, 4% miscellaneous) were included by five participating centers. The population was stratified into patients with small (≤15 mm CPA on axial MRI views) and large tumors. In each group, patients were randomized to receive corticosteroid (1 mg/kg/day i.v. methylprednisolone intraoperatively and at postoperative days 1-5) or placebo. Steroids did not affect the facial function at postoperative days 1, 8 and 30 in patients with small or large tumors as evaluated by House and Brackmann grading. © 2015 S. Karger AG, Basel
- Subjects
HORMONE therapy; CORTICOSTEROIDS; TREATMENT of facial paralysis; NERVOUS system injuries; CEREBELLOPONTILE angle; ACOUSTIC neuroma; SURGERY
- Publication
Audiology & Neurotology, 2015, Vol 20, Issue 4, p213
- ISSN
1420-3030
- Publication type
Article
- DOI
10.1159/000370191