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- Title
Stargazin modulates AMPA receptor gating and trafficking by distinct domains.
- Authors
Tomita, Susumu; Adesnik, Hillel; Sekiguchi, Masayuki; Wei Zhang; Wada, Keiji; Howe, James R.; Nicoll, Roger A.; Bredt, David S.
- Abstract
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors mediate fast excitatory synaptic transmission in the brain. These ion channels rapidly deactivate and desensitize, which determine the time course of synaptic transmission. Here, we find that the AMPA receptor interacting protein, stargazin, not only mediates AMPA receptor trafficking but also shapes synaptic responses by slowing channel deactivation and desensitization. The cytoplasmic tail of stargazin determines receptor trafficking, whereas the ectodomain controls channel properties. Stargazin alters AMPA receptor kinetics by increasing the rate of channel opening. Disrupting the interaction of stargazin ectodomain with hippocampal AMPA receptors alters the amplitude and shape of synaptic responses, establishing a crucial function for stargazin in controlling the efficacy of synaptic transmission in the brain.
- Subjects
ION channels; PROPIONIC acid; MEMBRANE proteins; CYTOPLASM; SYNAPSES; HIPPOCAMPUS (Brain)
- Publication
Nature, 2005, Vol 435, Issue 7045, p1052
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature03624