We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Virtual screening of chemical libraries.
- Authors
Shoichet, Brian K.
- Abstract
Virtual screening uses computer-based methods to discover new ligands on the basis of biological structures. Although widely heralded in the 1970s and 1980s, the technique has since struggled to meet its initial promise, and drug discovery remains dominated by empirical screening. Recent successes in predicting new ligands and their receptor-bound structures, and better rates of ligand discovery compared to empirical screening, have re-ignited interest in virtual screening, which is now widely used in drug discovery, albeit on a more limited scale than empirical screening.
- Subjects
DIAGNOSIS; MORPHOLOGY; CLINICAL medicine; LIGANDS (Biochemistry); COMPARATIVE anatomy
- Publication
Nature, 2004, Vol 432, Issue 7019, p862
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature03197