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- Title
Suppression of the Antioxidant System and PI3K/Akt/mTOR Signaling Pathway in Cisplatin-Resistant Cancer Cells by Quercetin.
- Authors
Hasan, A. A. Sh.; Kalinina, E. V.; Tatarskiy, V. V.; Volodina, Yu. L.; Petrova, А. S.; Novichkova, M. D.; Zhdanov, D. D.; Shtil, A. A.
- Abstract
We studied the effect of quercetin on ovarian adenocarcinoma SKOV-3 cell line and isogenic subline SKOV-3/CDDP resistant to the anticancer drug cisplatin. It was found that in resistant cells, quercetin in a concentration of 100 μM that causes a decrease in the cell viability suppressed the expression of genes encoding the key antioxidant enzymes (SOD2, CAT, GPX1, and HO-1), transcription factor Nrf2, and kinases of the PI3K/Akt/mTOR signaling pathway. In parental cells, quercetin, on the contrary, increased the expression of these genes. The results confirm the redox-dependent regulation induced by quercetin and its opposite nature in cisplatin-sensitive and cisplatin-resistant cancer cells.
- Subjects
QUERCETIN; CISPLATIN; CELLULAR signal transduction; DRUG resistance in cancer cells; OVARIES
- Publication
Bulletin of Experimental Biology & Medicine, 2022, Vol 173, Issue 6, p760
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-022-05626-9