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- Title
On the determinants of IDO activity in patients with familial Mediterranean fever.
- Authors
Deshayes, Samuel; Callebert, Jacques; Launay, Jean-Marie; Aouba, Achille; Sokol, Harry; Georgin-Lavialle, Sophie
- Abstract
This article discusses the determinants of indoleamine 2,3-dioxygenase (IDO) activity in patients with familial Mediterranean fever (FMF). The authors highlight the importance of studying the kynurenine pathway (KP) of tryptophan metabolism in FMF due to the increased levels of proinflammatory cytokines in these patients, which enhance IDO activity. They also suggest that the gut microbiota dysbiosis associated with FMF may modulate tryptophan metabolism. The authors propose that further research on the KP and its relationship with the gut microbiota is necessary in order to better understand the pathogenesis of FMF and related conditions.
- Subjects
FAMILIAL Mediterranean fever; INDOLEAMINE 2,3-dioxygenase; ARYL hydrocarbon receptors
- Publication
Modern Rheumatology, 2023, Vol 33, Issue 3, p629
- ISSN
1439-7595
- Publication type
Article
- DOI
10.1093/mr/roac045