We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Anti-inflammatory Effect of Rosmarinic Acid and an Extract of Rosmarinus officinalis in Rat Models of Local and Systemic Inflammation.
- Authors
Rocha, Joao; Eduardo‐Figueira, Maria; Barateiro, Andreia; Fernandes, Adelaide; Brites, Dora; Bronze, Rosario; Duarte, Catarina MM; Serra, Ana Teresa; Pinto, Rui; Freitas, Marisa; Fernandes, Eduarda; Silva‐Lima, Beatriz; Mota‐Filipe, Helder; Sepodes, Bruno
- Abstract
Rosmarinic acid is a polyphenolic compound and main constituent of Rosmarinus officinalis and has been shown to possess antioxidant and anti-inflammatory properties. We aimed to evaluate the anti-inflammatory properties of rosmarinic acid and of an extract of R. officinalis in local inflammation (carrageenin-induced paw oedema model in the rat), and further evaluate the protective effect of rosmarinic acid in rat models of systemic inflammation: liver ischaemia-reperfusion (I/R) and thermal injury models. In the local inflammation model, rosmarinic acid was administered at 10, 25 and 50 mg/kg (p.o.), and the extract was administered at 10 and 25 mg/kg (equivalent doses to rosmarinic acid groups) to male Wistar rats. Administration of rosmarinic acid and extract at the dose of 25 mg/kg reduced paw oedema at 6 hr by over 60%, exhibiting a dose-response effect, suggesting that rosmarinic was the main contributor to the anti-inflammatory effect. In the liver I/R model, rosmarinic acid was administered at 25 mg/kg (i.v.) 30 min. prior to the induction of ischaemia and led to the significant reduction in the serum concentration of transaminases ( AST and ALT) and LDH. In the thermal injury model, rosmarinic acid was administered at 25 mg/kg (i.v.) 5 min. prior to the induction of injury and significantly reduced multi-organ dysfunction markers (liver, kidney, lung) by modulating NF-κB and metalloproteinase-9. For the first time, the anti-inflammatory potential of rosmarinic acid has been identified, as it causes a substantial reduction in inflammation, and we speculate that it might be useful in the pharmacological modulation of injuries associated to inflammation.
- Subjects
ROSEMARY; POLYPHENOLS; CARRAGEENANS; AMINOTRANSFERASES; GASTROINTESTINAL diseases
- Publication
Basic & Clinical Pharmacology & Toxicology, 2015, Vol 116, Issue 5, p398
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/bcpt.12335