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- Title
New Quinone Antibiotics against Methicillin-Resistant S. aureus.
- Authors
Campanini-Salinas, Javier; Andrades-Lagos, Juan; Hinojosa, Nicolás; Moreno, Fabián; Alarcón, Pedro; González-Rocha, Gerardo; Burbulis, Ian E.; Vásquez-Velásquez, David
- Abstract
There is an urgent need for the development of new antibiotics. Here, we describe the inhibitory activity of new quinone compounds against methicillin-resistant Staphylococcus aureus (ATCC® 43300), methicillin-sensitive S. aureus (ATCC® 29213), and two clinical isolates from Chile (ISP-213 and ISP-214). We observed 99.9% reduction in viability within 2 h of exposure without the cultures exhibiting any post-antibiotic effect, which was twice the kinetics to that observed with vancomycin. These clinical isolates did not acquire resistance to these quinone derivatives during the course of our study. We found that these compounds protected larvae of the greater wax moth, sp. Galleria mellonella, from infection by these MRSA clinical strains as effectively as vancomycin. These quinone derivatives are potential drug candidates worth further development.
- Subjects
CHILE; GREATER wax moth; ANTIBIOTICS; METHICILLIN-resistant staphylococcus aureus; QUINONE compounds; QUINONE derivatives
- Publication
Antibiotics (2079-6382), 2021, Vol 10, Issue 6, p614
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics10060614