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- Title
Efficacy and Safety of Heterologous Booster Vaccination after Ad5-nCoV (CanSino Biologics) Vaccine: A Preliminary Descriptive Study.
- Authors
Muñoz-Valle, José Francisco; Sánchez-Zuno, Gabriela Athziri; Matuz-Flores, Mónica Guadalupe; Hernández-Ramírez, Cristian Oswaldo; Díaz-Pérez, Saúl Alberto; Baños-Hernández, Christian Johana; Turrubiates-Hernández, Francisco Javier; Vega-Magaña, Alejandra Natali; Hernández-Bello, Jorge
- Abstract
Several studies have reported the benefits and safety of heterologous vaccination among different approved vaccines; however, there are no specific reports on the effects of vaccination with the Ad5-nCoV and other vaccines of the same or different technologies. In the present study, we evaluated the neutralizing antibodies percentage against SARS-CoV-2 in Mexican patients immunized with the Ad5-nCoV vaccine six months after its application. Moreover, the effect of the heterologous vaccination with the Ad5-nCoV vaccine and a booster dose of ChAdOx1-S-Nov-19, Ad26.COV2.S, BNT162b2, or mRNA-127 were determined. Our results suggest that a heterologous regimen of one dose with Ad5-nCoV vaccine followed by a booster dose of a different vaccine is safe and induces a stronger humoral immune response.
- Subjects
BOOSTER vaccines; BIOLOGICALS; VACCINES; HUMORAL immunity; VACCINE approval
- Publication
Vaccines, 2022, Vol 10, Issue 3, p400
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines10030400