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- Title
A Unique Genome-wide Association Study of a Psychiatric Disorder From India.
- Authors
Nimgaonkar, Vishwajit L.; Wood, Joel; Deshpande, Smita
- Abstract
In other words, when the investigators compared the frequency of alleles (variants) from a panel of single-nucleotide polymorphisms, the frequency of allele A of this biallelic genetic polymorphism was significantly higher among patients with schizophrenia than control participants, based on a genome-wide association study (GWAS). The authors[1] thus contend that the A allele of rs10866912 is a risk factor for schizophrenia. The extended time span meant that genotyping assays were conducted in 4 stages, so only 26 939 linkage disequilibrium-independent single-nucleotide polymorphisms were assayed uniformly in all the samples.
- Subjects
MENTAL illness; MENTAL health surveys; NIACIN; DNA copy number variations
- Publication
JAMA Psychiatry, 2019, Vol 76, Issue 10, p1003
- ISSN
2168-622X
- Publication type
editorial
- DOI
10.1001/jamapsychiatry.2019.1325