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- Title
The Effects of Apium graveolens and Eucalyptus globulus in Decreasing Stress and Protecting Folliculogenesis Marker on Woman Reproductive Health during COVID-19 Pandemic.
- Authors
Novika, Revi Gama Hatta; Nurhidayati, Siti; Wahidah, Nurul Jannatul; Maulina, Rufidah; Sumarno, Lanjar; Yunus, Ahmad; Rahmawati, Nanda Yuli; Ansori, Arif Nur Muhammad
- Abstract
Stress during Coronavirus disease-2019 (COVID-19) pandemic affects the physiological and immunological response to women's reproductive health. Meanwhile, Apium graveolens and Eucalyptus globulus are immunomodulators related to women's reproductive health. This investigation had a goal to examine the effectiveness of A. graveolens and E. globulus towards the expression of Heat Shock Protein-70 (HSP70) as the primary biomarker of stress, Tumor Necrosis Factor-Alpha (TNF-a) as a proinflammatory protein, along with Luteinizing Hormone (LH) and Growth Differentiation Factor 9 (GDF-9) as folliculogenesis markers. An experimental randomized controlled trial was utilized by using a pre-test and post-test control group design. Sixty women, who had stress based on DASS-21 questionnaire, were divided into two groups in Nusukan Health Center, Indonesia. The intervention group was orally administered with 300 mg A. graveolens capsules and E. globulus essential oil for 14 days, while the control group was given a placebo. Blood samples and stress levels were then evaluated before and after the intervention. No significant difference was found in the stress levels of the control and treatment groups at the pre-test. Meanwhile, the intervention group had the decreased HSP70, TNF-a, and stress levels (p<0.001). In contrast, increased LH and GDF-9 levels were displayed in the intervention group compared to the control group (p<0.001). These findings revealed that A. graveolens supplementation and E. globulus essential oil have the ability to decrease stress and are able to protect folliculogenesis markers on women's reproductive health due to stressful conditions during pandemic COVID-19.
- Subjects
INDONESIA; COVID-19 pandemic; CELERY; EUCALYPTUS globulus; GROWTH differentiation factors; TUMOR necrosis factors; WOMEN'S health
- Publication
Indonesian Journal of Pharmacy / Majalah Farmasi Indonesia, 2022, Vol 33, Issue 4, p592
- ISSN
0126-1037
- Publication type
Article