We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Effect of Lactofem Oral Probiotic Capsule on Lactobacilli Colonization and Some Vaginal Health Parameters.
- Authors
Balaghi, Zohreh; Azima, Sara; Motamedifar, Mohammad; Kaviani, Maasumeh; Poordast, Tahereh; Zare, Najaf
- Abstract
<bold>Background and Objective: </bold>Healthy vaginal ecosystem is conserved with the connection of vaginal epithelium and flora in which lactobacilli play a significant role. The present study aimed to examine the effect of lactofem oral probiotic capsule on Lactobacillus colonization and some other vaginal health indices in women aged 18-55 years.<bold>Materials and Methods: </bold>This interventional, double-blind controlled clinical trial was conducted on 70 women with Nugent score = 4-6 and vaginal pH >4.5. The participants were divided into an oral probiotic group and a control group. The oral probiotic group was required to take one 500 mg lactofem capsule daily for 2 months, while placebo was prescribed for the control group. Samples from 6 visits were examined during the period of prescription. The data were analyzed using the SPSS statistical software, version 18.<bold>Results: </bold>The results showed no significant difference in the average colonization of vaginal Lactobacillus in the 2 groups before and during the intervention (p = 0.26). Also, no significant difference was observed in the 2 groups' Nugent mean scores before and after the intervention up to the 60th day. However, a statistically significant difference was found in this regard on the 70th day (p = 0.032). Moreover, the results indicated no significant difference in the 2 groups' mean vaginal pH before and after the intervention (p = 0.101).<bold>Conclusion: </bold>Lactofem oral capsule could improve the participants' Nugent scores, but caused no change in Lactobacillus colonization or vaginal pH.
- Subjects
COLONIZATION; CLINICAL trials; STATISTICAL software
- Publication
Gynecologic & Obstetric Investigation, 2020, Vol 85, Issue 3, p245
- ISSN
0378-7346
- Publication type
journal article
- DOI
10.1159/000506802