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- Title
β-Catenin expression in the transitional cell zone of pilomatricoma.
- Authors
Park, S-W.; Suh, K-S.; Wang, H-Y.; Kim, S-T.; Sung, H-S.
- Abstract
Background β-Catenin, a participant in the Wnt pathway, has been shown to play an important role in the morphogenesis of hair follicles and the formation of hair follicle-related tumours, including pilomatricomas. It has been observed that at least 75% of human pilomatricomas possess activating mutations in β-catenin. These findings suggested that β-catenin plays an important role in the tumorigenesis of pilomatricomas. However, the pattern of β-catenin expression in pilomatricoma tissues is still unclear. Objectives To examine the expression of β-catenin in human pilomatricomas by immunohistochemical staining. Methods Twenty-six formalin-fixed and paraffin-embedded samples of pilomatricoma tissue were studied. Results Most transitional cells of pilomatricoma expressed β-catenin strongly, but the basophilic cells and shadow cells did not. β-Catenin showed a prominent membranous immunoreactivity and a small amount of condensed cytoplasmic staining, but there was definitely no evidence of nuclear positivity. Conclusions These findings imply that β-catenin is primarily involved in cell–cell adhesion rather than cellular proliferation during pilomatricoma pathogenesis, and suggest that if β-catenin is involved in pilomatricoma tumorigenesis and tumour growth, it plays an indirect role.
- Subjects
TUMORS; HAIR follicles; CARCINOGENESIS; CELL adhesion
- Publication
British Journal of Dermatology, 2001, Vol 145, Issue 4, p624
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1046/j.1365-2133.2001.04433.x