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- Title
Anti -- nuclear RNP antibodies in two sisters.
- Authors
Shiiki, H.; Miyagawa, S.; Dohi, K.; Yamada, H.; Hanatani, M.; Ishikawa, H.
- Abstract
Two sisters with clinical elements of mixed connective tissue disease were found to have anti-nuclear RNP (nRNP) antibodies. These antibodies were not found in the six other family members examined. The sisters had inherited an identical HLA haplotype A2-Bw61- Cw3-DR1 from their mother who had had Raynaud's phenomenon for several years. Analysis of peripheral lymphocyte subsets in the patients and their immediate relatives showed decreased OKT-4-positive cells in one of the patients and increased OKT-8-positive cells in both patients, their father and their brother, resulting in lower OKT 4/OKT 8 ratios in these members of the family. This is the third description of the familial occurrence of anti-nRNP antibodies and it adds further evidence for the implication of genetic factors in the development of anti-nRNP antibodies.
- Subjects
IMMUNOGLOBULINS; GLOBULINS; PLASMA cells; BLOOD proteins; COLLAGEN; CONNECTIVE tissues; TISSUES
- Publication
British Journal of Dermatology, 1985, Vol 113, Issue 5, p617
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1985.tb02388.x