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- Title
Synthesis of Hydrazones from Amino Acids and their Antimicrobial and Cytotoxic Activities.
- Authors
Abid, Obaid ‐ ur ‐ Rahman; Khatoon, Ghamama; Arfan, Muhammad; Sajid, Imran; Langer, Peter; Rehman, Wajid; Rahim, Fazal; Yasir, Muhammad; Waqar, Muhammad; Haleem, Kashif Syed
- Abstract
Hydrazones 6a-6n were synthesized from different amino acids with various aldehydes under reflux in methanol/ethanol. The structures of synthesized compounds were ascertained by elemental analysis and spectroscopic techniques. A comparative study of the antimicrobial activity and cytotoxicity was carried out of the N-protected amino acids, their esters, hydrazides, and the respective hydrazones, providing good results in cytotoxicity studies.
- Subjects
HYDRAZONES; CHEMICAL synthesis; AMINO acids; ANTI-infective agents; ANTINEOPLASTIC antibiotics
- Publication
Journal of the Chinese Chemical Society, 2017, Vol 64, Issue 9, p1079
- ISSN
0009-4536
- Publication type
Article
- DOI
10.1002/jccs.201600859