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- Title
Variability of Insulin Requirements Over 12 Weeks of Closed-Loop Insulin Delivery in Adults With Type 1 Diabetes.
- Authors
Yue Ruan; Thabit, Hood; Leelarathna, Lalantha; Hartnell, Sara; Willinska, Malgorzata E.; Dellweg, Sibylle; Benesch, Carsten; Mader, Julia K.; Holzer, Manuel; Kojzar, Harald; Evans, Mark L.; Pieber, Thomas R.; Arnolds, Sabine; Hovorka, Roman; Ruan, Yue; AP@home Consortium
- Abstract
<bold>Objective: </bold>To quantify variability of insulin requirements during closed-loop insulin delivery.<bold>Research Design and Methods: </bold>We retrospectively analyzed overnight, daytime, and total daily insulin amounts delivered during a multicenter closed-loop trial involving 32 adults with type 1 diabetes. Participants applied hybrid day-and-night closed-loop insulin delivery under free-living home conditions over 12 weeks. The coefficient of variation was adopted to measure variability of insulin requirements in individual subjects.<bold>Results: </bold>Data were analyzed from 1,918 nights, 1,883 daytime periods and 1,564 total days characterized by closed-loop use over 85% of time. Variability of overnight insulin requirements (mean [SD] coefficient of variation 31% [4]) was nearly twice as high as variability of total daily requirements (17% [3], P < 0.001) and was also higher than variability of daytime insulin requirements (22% [4], P < 0.001).<bold>Conclusions: </bold>Overnight insulin requirements were significantly more variable than daytime and total daily amounts. This may explain why some people with type 1 diabetes report frustrating variability in morning glycemia.
- Subjects
INSULIN; TYPE 1 diabetes; VARIABILITY (Psychometrics); GLYCEMIC control; DRUG delivery systems; PATIENTS; BLOOD sugar; COMPARATIVE studies; CROSSOVER trials; HYPOGLYCEMIC agents; INSULIN pumps; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; EVALUATION research; RETROSPECTIVE studies
- Publication
Diabetes Care, 2016, Vol 39, Issue 5, p830
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc15-2623