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- Title
Association of genetic variation of the RIL gene, encoding a PDZ-LIM domain protein and localized in 5q31.1, with low bone mineral density in adult Japanese women.
- Authors
Omasu, Fumihiro; Ezura, Yoichi; Kajita, Mitsuko; Ishida, Ryota; Kodaira, Mina; Yoshida, Hideo; Suzuki, Takao; Hosoi, Takayuki; Inoue, Satoshi; Shiraki, Masataka; Orimo, Hajime; Emi, Mitsuru
- Abstract
Twin and family studies had shown that genetic factors are important determinants of bone mass. Multiple genes might be involved. One candidate gene, the reversion-induced LIM gene (RIL), is a PDZ and LIM-domain-containing protein and has been localized within the cytokine cluster of chromosome 5 (5q31.1). In a genetic study of 370 adult Japanese women, we investigated the correlation between radial bone mineral density (BMD) and a genetic variation (-3333T → C) of the 5'-flanking region of RIL gene. A significant association was identified between the RIL variation (-3333T → C and radial BMD (r=0.15,P=0.003). The variation of the RIL locus may be an important determinant of osteoporosis.
- Subjects
JAPAN; BONE densitometry; HUMAN genetic variation; RADIAL bone
- Publication
Journal of Human Genetics, 2003, Vol 48, Issue 7, p342
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s10038-003-0035-1