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- Title
Emerging Coxsackievirus A6 Causing Hand, Foot and Mouth Disease, Vietnam.
- Authors
Nguyen To Anh; Le Nguyen Truc Nhu; Hoang Minh Tu Van; Nguyen Thi Thu Hong; Tran Tan Thanh; Vu Thi Ty Hang; Nguyen Thi Han Ny; Lam Anh Nguyet; Tran Thi Lan Phuong; Le Nguyen Thanh Nhan; Nguyen Thanh Hung; Truong Huu Khanh; Ha Manh Tuan; Ho Lu Viet; Nguyen Tran Nam; Do Chau Viet; Phan Tu Qui; Wills, Bridget; Sabanathan, Sarawathy; Nguyen Van Vinh Chau
- Abstract
Hand, foot and mouth disease (HFMD) is a major public health issue in Asia and has global pandemic potential. Coxsackievirus A6 (CV-A6) was detected in 514/2,230 (23%) of HFMD patients admitted to 3 major hospitals in southern Vietnam during 2011-2015. Of these patients, 93 (18%) had severe HFMD. Phylogenetic analysis of 98 genome sequences revealed they belonged to cluster A and had been circulating in Vietnam for 2 years before emergence. CV-A6 movement among localities within Vietnam occurred frequently, whereas viral movement across international borders appeared rare. Skyline plots identified fluctuations in the relative genetic diversity of CV-A6 corresponding to large CV-A6-associated HFMD outbreaks worldwide. These data show that CV-A6 is an emerging pathogen and emphasize the necessity of active surveillance and understanding the mechanisms that shape the pathogen evolution and emergence, which is essential for development and implementation of intervention strategies.
- Subjects
VIETNAM; COXSACKIEVIRUS diseases; FOOT &; mouth disease; PUBLIC health; NUCLEOTIDE sequencing; VIRAL transmission; COMMUNICABLE disease epidemiology; COMMUNICABLE diseases; COMPARATIVE studies; ENTEROVIRUSES; BIOLOGICAL evolution; GENOMES; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; GENOMICS; EVALUATION research; HAND, foot &; mouth disease
- Publication
Emerging Infectious Diseases, 2018, Vol 24, Issue 4, p654
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2404.171298