We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Associations between Mycobacterium tuberculosis Strains and Phenotypes.
- Authors
Brown, Timothy; Nikolayevskyy, Vladyslav; Velji, Preya; Drobniewski, Francis
- Abstract
To inform development of tuberculosis (TB) control strategies, we characterized a total of 2,261 Mycobacterium tuberculosis complex isolates by using multiple phenotypic and molecular markers, including polymorphisms in repetitive sequences (spoligotyping and variable-number tandem repeats [VNTRs]) and large sequence and single-nucleotide polymorphisms. The Beijing family was strongly associated with multidrug resistance (p = 0.0001), and VNTR allelic variants showed strong associations with spoligotyping families: ≥5 copies at exact tandem repeat (ETR) A, ≥2 at mycobacterial interspersed repetitive unit 24, and ≥3 at ETR-B associated with the East African-Indian and M. bovis strains. All M. tuberculosis isolates were differentiated into 4 major lineages, and a maximum parsimony tree was constructed suggesting a more complex phylogeny for M. africanum. These findings can be used as a model of pathogen global diversity.
- Subjects
MYCOBACTERIUM tuberculosis; NUCLEOTIDES; MULTIDRUG resistance; PHYLOGENY; PHENOTYPES; BIOMARKERS
- Publication
Emerging Infectious Diseases, 2010, Vol 16, Issue 2, p272
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1602.091032