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- Title
Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma.
- Authors
Wang, C.-C.; Fu, C.-L.; Yang, Y.-H.; Lo, Y.-C.; Wang, L.-C.; Chuang, Y.-H.; Chang, D.-M.; Chiang, B.-L.
- Abstract
Interleukin-1 (IL-1) is a proinflammatory cytokine and IL-1 receptor antagonist (IL-1ra) is a natural inhibitor that binds to IL-1 receptor type I without inducing signal transduction. It is suggested that IL-1 is required for allergen-specific T helper type 2 cell activation and the development of airway hyper-responsiveness (AHR), but the immunologic effect of exogenous IL-1ra in allergic asthma remains unclear. To examine the effect of IL-1ra on airway inflammation and immunoeffector cells in allergic asthma, recombinant adenovirus expressing human IL-1ra (Ad-hIL-1ra) was delivered intranasally into ovalbumin (OVA)-immunized mice. Single intranasal administration of Ad-hIL-1ra before airway antigen challenge in OVA-immunized mice significantly decreased the severity of AHR and reduced pulmonary infiltration of eosinophils and neutrophils. Suppression of IL-5 and eotaxin with concomitant enhancement of interferon gamma in bronchoalveolar lavage fluid was also noted in OVA-immunized mice by administration of Ad-hIL-1ra. In addition, histological studies showed that Ad-hIL-1ra was able to decrease OVA-induced peribronchial inflammation. Taken together, our results indicated that administration of Ad-hIL-1ra may have therapeutic potential for the immunomodulatory treatment of allergic asthma.Gene Therapy (2006) 13, 1414–1421. doi:10.1038/sj.gt.3302798; published online 25 May 2006
- Subjects
ASTHMA; INTERLEUKIN-1; ADENOVIRUSES; EOSINOPHILS; NEUTROPHILS; RECOMBINANT viruses
- Publication
Gene Therapy, 2006, Vol 13, Issue 19, p1414
- ISSN
0969-7128
- Publication type
Article
- DOI
10.1038/sj.gt.3302798