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- Title
False positivity of anti aquaporin-4 antibodies in natalizumab-treated patients.
- Authors
Cohen, Mikael; De Sèze, Jérome; Marignier, Romain; Lebrun, Christine
- Abstract
Background: Neuromyelitis optica spectrum disorders (NMOSD) represent a differential diagnosis of multiple sclerosis (MS). Detection of anti-aquaporin-4 antibodies (AQP4-Ab) is the strongest argument to confirm NMOSD. Diagnosing NMOSD is a major concern because specific MS disease modifying drugs can lead to neurological worsening. Objective: To report the case of two natalizumab (NTZ) treated patients who presented a false positive result for AQP4-Ab. Methods: A retrospective analysis of NTZ-treated patients who were tested positive for AQP4-Ab in our MS center. Results: Two patients treated by NTZ presented a false positive result. Conclusions: Clinicians should be aware of potential technical issues in detecting AQP4-Ab in NTZ-treated patients leading to false positive results.
- Subjects
MULTIPLE sclerosis; NATALIZUMAB; NEUROMYELITIS optica; AQUAPORINS; PATIENTS
- Publication
Multiple Sclerosis Journal, 2016, Vol 22, Issue 9, p1231
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458516630823