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- Title
Validating Neuro-QoL short forms and targeted scales with people who have multiple sclerosis.
- Authors
Miller, Deborah M.; Bethoux, Francois; Victorson, David; Nowinski, Cindy J.; Buono, Sarah; Lai, Jin-Shei; Wortman, Katy; Burns, James L.; Moy, Claudia; Cella, David
- Abstract
Background: Multiple sclerosis (MS) is a chronic, progressive, and disabling disease of the central nervous system with dramatic variations in the combination and severity of symptoms it can produce. The lack of reliable disease-specific health-related quality of life (HRQL) measures for use in clinical trials prompted the development of the Neurology Quality of Life (Neuro-QOL) instrument, which includes 13 scales that assess physical, emotional, cognitive, and social domains, for use in a variety of neurological illnesses. Objective: The objective of this research paper is to conduct an initial assessment of the reliability and validation of the Neuro-QOL short forms (SFs) in MS. Methods: We assessed reliability, concurrent validity, known groups validity, and responsiveness between cross-sectional and longitudinal data in 161 recruited MS patients. Results: Internal consistency was high for all measures (α = 0.81--0.95) and ICCs were within the acceptable range (0.76-0.91); concurrent and known groups validity were highest with the Global HRQL question. Longitudinal assessment was limited by the lack of disease progression in the group. Conclusions: The Neuro-QOL SFs demonstrate good internal consistency, test-re-test reliability, and concurrent and known groups validity in this MS population, supporting the validity of Neuro-QOL in adults with MS.
- Subjects
MULTIPLE sclerosis research; DEMYELINATION; MYELIN sheath diseases; VIRUS diseases; QUALITY of life
- Publication
Multiple Sclerosis Journal, 2016, Vol 22, Issue 6, p830
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458515599450