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- Title
Formulation and evaluation of Xylazine Hydrochloride mouth dissolving film.
- Authors
Sharma, Ayushi; Joshi, Ankur; Pathan, Javed; Vyas, Narendra; Malviya, Sapna; Kharia, Anil
- Abstract
Xylazine hydrochloride is widely used in the treatment of multiple sclerosis spastic diplegia back pain or certain injuries to the spine or CNS, Xylazine hydrochloride has been found to be effective other antispasmodic drug and has superior tolerability to that baclofen and diazepam. The present study is deals with formulation, and evaluation of Xylazine hydrochloride mouth dissolving films. Xylazine hydrochloride is one of the drug which is used in the treatment of above The mouth dissolving films was prepared by using solvent casting method. The concentration of Sodium alginate, Glycerol, Tween 80 were kept constant in all formulations (F1-F4) and varying concentration of all the formulations were evaluated for surface pH, weight uniformity, folding endurance, drug content, disintegration time, in-vitro dissolution studies. The formulation 'F3' was found to be optimized formulation. It shows results for all evaluation parameters such as weight variation 84.56±0.22 mg, surface pH 6.10 ±0.45, folding endurance > 100, drug content 84.10±0.20%, disintegration time 28±0.50 sec, and in-vitro dissolution study 63.71 % at the end of 5 min. From all of observation we can conclude that the formulation F3 shows better results.
- Subjects
XYLAZINE; CHLORIDES; BACLOFEN; DIAZEPAM; SODIUM alginate
- Publication
International Journal of Pharmacy & Life Sciences, 2017, Vol 8, Issue 5, p42
- ISSN
0976-7126
- Publication type
Article