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- Title
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.
- Authors
Jensen, Dane D.; Lieu, TinaMarie; Halls, Michelle L.; Veldhuis, Nicholas A.; Imlach, Wendy L.; Quynh N. Mai; Poole, Daniel P.; Quach, Tim; Aurelio, Luigi; Conner, Joshua; Klein Herenbrink, Carmen; Barlow, Nicholas; Simpson, Jamie S.; Scanlon, Martin J.; Graham, Bimbil; McCluskey, Adam; Robinson, Phillip J.; Escriou, Virginie; Nassini, Romina; Materazzi, Serena
- Abstract
The article presents a study which shows the important role for endosomal signaling of the neurokinin one (NK1R) in the complex pathophysiology of pain and demonstrate the use of endosomally targeted G protein coupled receptors (GPCR) antagonists. Endosomal receptors that generate signals that control complex processes in vivo and are viable therapeutic targets is explored. Sustained substance-induced excitation of neurons in spinal cord slices in vitro is cited.
- Subjects
TACHYKININS; NEUROPEPTIDES; G proteins; MEMBRANE proteins; NEURONS
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 392, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aal3447