We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma.
- Authors
Navarro, Severine; Pickering, Darren A.; Ferreira, Ivana B.; Jones, Linda; Ryan, Stephanie; Troy, Sally; Leech, Andrew; Hotez, Peter J.; Bin Zhan; Laha, Thewarach; Prentice, Roger; Sparwasser, Tim; Croese, John; Engwerda, Christian R.; Upham, John W.; Julia, Valerie; Giacomin, Paul R.; Loukas, Alex
- Abstract
The article discusses a study on the effect of anti-inflammatory protein-2 (AIP-2) secreted by hookworms on patients with asthma. The study used a mouse model to examine the role of the protein in the suppression of airway inflammation. It also investigated the role of the protein in the expression of costimulatory markers on dendritic cells (DCs) in human subjects and in the proliferation of ex vivo of T cells from patients with house dust mite allergy.
- Subjects
ASTHMA treatment; THERAPEUTIC use of proteins; HOOKWORMS; LABORATORY mice; PROTEIN expression; DENDRITIC cells; CELL proliferation; T cells
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 362, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaf8807