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- Title
Arrestins and G proteins in cellular signaling: The coin has two sides.
- Authors
Gurevich, Vsevolod V.; Gurevich, Eugenia V.
- Abstract
Several studies have suggested that arrestin-mediated signaling by GPCRs requires G protein activation; however, in this issue of Science Signaling, Luttrell et al. documented arrestin-dependent activation of ERK1/2 by a number of GPCRs. These studies do not contradict each other, but illustrate the complexity of cellular signaling that cannot and should not be reduced to simplistic models.
- Subjects
ARRESTINS; G proteins; MEMBRANE proteins; BIOLOGICAL membranes; CELL membranes
- Publication
Science Signaling, 2018, Vol 11, Issue 549, p1
- ISSN
1945-0877
- Publication type
Article
- DOI
10.1126/scisignal.aav1646