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- Title
Genetic Modifiers of Liver Disease in Cystic Fibrosis.
- Authors
Bartlett, Jaclyn R.; Friedman, Kenneth J.; Ling, Simon C.; Pace, Rhonda G.; Bell, Scott C.; Bourke, Billy; Castaldo, Giuseppe; Castellani, Carlo; Cipolli, Marco; Colombo, Carla; Colombo, John L.; Debray, Dominique; Fernandez, Adriana; Lacaille, Florence; Macek Jr., Milan; Salvatore, Marion Rowland Francesco; Taylor, Christopher J.; Wainwright, Claire; Wilschanski, Michael; Zemková, Dana
- Abstract
The article details a study which examined if any of the nine polymorphisms in five candidate genes are associated with severe liver disease in patients diagnosed with cystic fibrosis (CF). The study included 124 patients with CF and severe liver disease with portal hypertension (CFLD) from centers in the U.S., Canada and outside of North America and 843 control subjects. The differences in the distribution of genotypes in the study population were analyzed. Study authors found that SERPINA1 Z allele is a risk factor for the development of liver disease in patients with CF.
- Subjects
UNITED States; CANADA; GENETIC polymorphisms; LIVER diseases; CYSTIC fibrosis; PORTAL hypertension; GENES; GENETICS
- Publication
JAMA: Journal of the American Medical Association, 2009, Vol 302, Issue 10, p1076
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2009.1295