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- Title
Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men.
- Authors
Lapauw B; Ouwens M; 't Hart LM; Wuyts B; Holst JJ; T'sjoen G; Kaufman JM; Ruige JB; Lapauw, Bruno; Ouwens, Margriet; 't Hart, Leen M; Wuyts, Birgitte; Holst, Jens J; T'Sjoen, Guy; Kaufman, Jean-Marc; Ruige, Johannes B
- Abstract
<bold>Objective: </bold>To evaluate metabolic effects of sex steroids in nonfasting and fasting conditions, independent from changes in body composition.<bold>Research Design and Methods: </bold>A randomized clinical trial was performed to create contrasting sex steroid levels in healthy young men: by letrozole (aromatase inhibitor) to lower estradiol (E(2)) and increase testosterone (group T, n = 10) versus letrozole plus E(2) patches to lower T and raise E(2) (group E, n = 10). Mixed meals and hyperinsulinemic-euglycemic clamps were performed before and after a 1-week treatment period.<bold>Results: </bold>Following intervention, the postprandial triglyceride response displayed a diverging response with a decline in group T and an increase in group E; the postprandial glucose-dependent insulinotropic polypeptide (GIP) response increased in group T. Insulin sensitivity increased in group T but remained unaltered in group E.<bold>Conclusions: </bold>In healthy young men, short-term changes in sex steroids affect postprandial triglyceride and GIP response and insulin sensitivity.
- Publication
Diabetes Care, 2010, Vol 33, Issue 8, p1831
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc10-0515