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- Title
Serum procalcitonin concentration within 2 days postoperatively accurately predicts outcome after liver resection.
- Authors
Yuto Aoki; Nobuhiko Taniai; Masato Yoshioka; Youichi Kawano; Tetsuya Shimizu; Tomohiro Kanda; Ryota Kondo; Yohei Kaneya; Hiroyasu Furuki; Eiji Uchida
- Abstract
Background: Relatively high mortality and morbidity rates are reported after liver resection (LR). However, the early predictors of complications after LR are not clear. This study was performed to clarify the usefulness of procalci- tonin (PCT) for the early prediction of complications after elective LR. Methods: This observational study included 72 consecutive patients who underwent elective LR from December 2015 to March 2017. Patients were categorized into two groups: those with and without postoperative complications (Clavien-Dindo grade ≥II). The values of post-operative inflammatory markers (white blood cell [WBC] count, C-reactive protein [CRP] and PCT) were compared between the two groups. Results: CRP and PCT were significantly higher in patients with than without complications; however, the WBC count showed no difference within 5 days postoperatively. The maximum area under the receiver operating characteristic curves within 2 days after LR using the WBC count, CRP and PCT were 0.608, 0.697 and 0.860, respectively, PCT had the best predictive ability in the early postoperative period. The PCT level peaked within 2 days postoperatively in 61 patients (85%). The maximum PCT level within 2 days postoperatively (PCT1-2) was significantly higher in patients with than without complications (0.52 vs. 0.19 ng/mL, p < 0.001). A cutoff PCT1-2 level of 0.35 ng/mL achieved 80% sensitivity and 83% specificity. In patients without complications, there was no difference in PCT1-2 even when the surgical procedure differed (p = 0.935). Conclusions: PCT1-2 is an early predictive marker after LR and can be similarly used regardless of the LR procedure.
- Subjects
LIVER surgery; SURGICAL excision; SURGICAL complications; SCIENTIFIC observation; BIOLOGICAL tags
- Publication
Clinical Chemistry & Laboratory Medicine, 2018, Vol 56, Issue 8, p1362
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2018-0196