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- Title
Estimates of Insulin Sensitivity Using Glucose and C-Peptide From the Hyperglycemia and Adverse Pregnancy Outcome Glucose Tolerance Test.
- Authors
Radaelli, Tatjana; Farrell, Kristen Anne; Huston-Presley, Larraine; Amini, Saeid Baradaran; Kirwan, John Patrick; McIntyre, Harold David; Catalano, Patrick Michael
- Abstract
OBJECTIVE -- To determine if glucose and C-peptide values obtained as part of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study could be used to estimate insulin sensitivity during late pregnancy. RESEARCH DESIGN AND METHODS -- A total of 78 women enrolled in the HAPO study were recruited for this ancillary study. Venous plasma samples were drawn after an 8- to 10-h fast (time 0) and at 30, 60, 90, and 120 rain after a 75-g glucose challenge, which was performed at 24-32 weeks' gestation. Samples were analyzed for plasma glucose, insulin, and C-peptide. Insulin sensitivity was estimated using the established Matsuda and DeFronzo insulin sensitivity index for oral glucose tolerance tests (IS[sub OGTT]). Insulin sensitivity was also calculated from two other commonly used indexes of insulin sensitivity (that for homeostasis model assessment [IS[sub HOMA]] and that for quantitative insulin sensitivity check index [IS[sub QUICKI]]). A new insulin sensitivity index was calculated using the glucose and C-peptide concentrations at 0 and 60 min to derive IS[sub HOMA C-pep], IS[sub QUICKI C-pep], and IS[sub OGTT C-pep]. These indexes were then correlated with insulin sensitivity estimated from the IS[sub OGTT]. RESULTS -- The strongest correlation with the IS[sub OGTT] was obtained for IS[sub OGTT C-pep] (r = 0.792, P < 0.001). Further, the correlations of IS[sub HOMA C-pep] and IS[sub QUICKI C-pep] with IS[sub OGTT] were also significant (r = 0.676, P < 0.001 and r = 0.707, P < 0.001, respectively). CONCLUSIONS -- These data suggest that calculated IS[sub OGTT C-pep] is an excellent predictor of insulin sensitivity in pregnancy and can be used to estimate insulin sensitivity in over 25,000 women participating in the HAPO study.
- Subjects
INSULIN; C-peptide; GLUCOSE; HYPERGLYCEMIA; PREGNANCY
- Publication
Diabetes Care, 2010, Vol 33, Issue 3, p490
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc09-1463