We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
MoMuLV-ts-1: A Unique Mouse Model of Retrovirus-Induced Lymphoma Transmitted by Breast Milk.
- Authors
Chakraborty, J.; Okonta, H.; Bagalb, H.; Duggan, J.
- Abstract
Our laboratory has developed a murine model of lymphoma via breast milk transmission of MoMuLV-ts-1 (Moloney murine leukemia virus-temperature sensitive mutant-1). Uninfected offspring suckled from infected surrogate mothers become infected and develop lymphoma. Multiple gene integration sites of ts-1 into the infected mouse genome including tacc3, aurka, ndel1, tpx2, p53, and rhamm were identified, and mRNA expressions were quantitated. These genes produce centrosomal proteins, which may be involved in abnormal chromosomal segregation leading to aneuploidy ormultiploidy, thus causing lymphoma. Since there is no report to date on this retroviral model leading to centrosomal abnormality, and causing lymphoma development, this is a valuable and unique model to study the centrosomal involvement in lymphomagenesis.
- Subjects
LABORATORY mice; LYMPHOMAS; BREASTFEEDING complications; RETROVIRUS diseases; MOUSE leukemia viruses; MESSENGER RNA; CANCER -- Transmission
- Publication
Advances in Virology, 2011, Vol 2011, p1
- ISSN
1687-8639
- Publication type
Article
- DOI
10.1155/2011/813651