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- Title
Saliva and plasma levels of cardiac-related biomarkers in post-myocardial infarction patients.
- Authors
Rathnayake, Nilminie; Buhlin, Kåre; Kjellström, Barbro; Klinge, Bjorn; Löwbeer, Christian; Norhammar, Anna; Rydén, Lars; Sorsa, Timo; Tervahartiala, Taina; Gustafsson, Anders; Faire, Ulf; hl, Bertil; Nygren, Åke; Näsman, Per; Svenungsson, Elisabet
- Abstract
Aim To relate cardiac biomarkers, such as cystatin C and growth differentiation factor-15 ( GDF-15) in saliva to myocardial infarction ( MI) and to periodontal status, and to investigate the relation between salivary and plasma cardiac biomarkers. Materials and Methods Two hundred patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6-10 weeks after the MI for patients and in close proximity thereafter for controls. Analysing methods: ARCHITECT i4000 SR, Immulite 2000 XPi or ELISA. Results The mean age was 62 ± 8 years and 84% were male. Total probing pocket depth, fibrinogen, white blood cell counts and HbA1c were higher in patients than controls. GDF-15 levels correlated with most of the included clinical variables in both study groups. No correlation was found between plasma and saliva levels of cystatin C or GDF-15. Conclusion Salivary cystatin C and GDF-15 could not differentiate between MI patients and controls.
- Subjects
SALIVA; BIOMARKERS; CARDIOLOGY; MYOCARDIAL infarction; CYSTATINS; PERIODONTAL disease; ENZYME-linked immunosorbent assay; FIBRINOGEN; GLYCOSYLATED hemoglobin; CARDIAC patients; HOSPITAL wards; PERIODONTIUM examination; CONTROL groups; CASE-control method; LEUKOCYTE count; BLOOD
- Publication
Journal of Clinical Periodontology, 2017, Vol 44, Issue 7, p692
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.12740