We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Circulating Levels of Adipocyte and Epidermal Fatty Acid-Binding Proteins in Relation to Nephropathy Staging and Macrovascular Complications in Type 2 Diabetic Patients.
- Authors
Yeung, Dennis C. Y.; Xu, Aimin; Tso, Annette W. K.; Chow, W. S.; Wat, Nelson M. S.; Fong, Carol H. Y.; Tam, Sidney; Sham, Pak C.; Lam, Karen S. L.
- Abstract
OBJECTIVE -- To investigate the relationships of serum adipocyte fatty acid-binding protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH DESIGN AND METHODS-- The associations of serum A-FABP and E-FABP with markers of renal function, nephropathy staging, and macrovascular complications were examined in 237 type 2 diabetic patients. RESULTS -- Serum A-FABP and E-FABP correlated significantly with serum creatinine, mean albumin excretion rate, and glomerular filtration rate (all P < 0.001) and were independently associated with diabetic nephropathy staging (P = 0.001 and P < 0.05, respectively). Circulating levels of both types of FABP were increased (P < 0.01) in subjects with macrovascular complications. Serum A-FABP was independently associated with macrovascular complications (odds ratio 2.92 [95% CI 1.42-6.01]; P = 0.004). CONCLUSIONS -- Serum A-FABP and E-FABP might be novel serum biomarkers for evaluating the progression of nephropathy and its cardiovascular risk in type 2 diabetic patients.
- Subjects
FATTY acid-binding proteins; FAT cells; SERUM; KIDNEY diseases; CARDIOVASCULAR diseases; TYPE 2 diabetes
- Publication
Diabetes Care, 2009, Vol 32, Issue 1, p132
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc08-1333