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- Title
Effects of small dose of brotizolam on P300.
- Authors
Hayakawa, Tatsuro; Uchiyama, Makoto; Enomoto, Tetsuro; Nakajima, Tsuneo; Kim, Keiko; Shibui, Kayo; Kudo, Yoshihisa; Ozaki, Shigeru; Nakajima, Toru; Suzuki, Hiroyuki; Urata, Jujiro; Okawa, Masako
- Abstract
AbstractNine healthy men (mean age, 22.2 years) participated in two experimental sessions cross-overed randomly in a double blind manner; one with a placebo and the other with 0.125 mg of brotizolam (BTZ) administered in the morning. Resting electroencephalogram and event-related potential under oddball paradigm was recorded before and 1, 2, 4, 6 and 8 h after the administration. Mean 30-msec bin amplitude from 240 msec to 450 msec after the stimulus was compared between placebo and drug sessions in order to observe P300. Brotizolam reduced the amplitude of P300 at 6 h after administration. It was noted that the effects of BTZ were most marked at Fz.
- Subjects
COGNITION disorders; TRIAZOLAM; EVOKED potentials (Electrophysiology)
- Publication
Psychiatry & Clinical Neurosciences, 2000, Vol 54, Issue 3, p319
- ISSN
1323-1316
- Publication type
Article
- DOI
10.1046/j.1440-1819.2000.00695.x