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- Title
Recruitment of Gr1CD11bF4/80 Population in the Bone Marrow and Spleen by Irradiation-Induced Pulmonary Damage.
- Authors
Thanasegaran, Suganya; Ito, Sachiko; Nishio, Naomi; Uddin, Mohammad; Sun, Yang; Isobe, Ken-ichi
- Abstract
Radiation-induced lung injury is a kind of sterile inflammation, which may lead to morbidity and mortality. The mechanism by which ionizing radiation activate the immune system is not well understood. In the present study, we have investigated the immunological responses induced by local irradiation-induced damage in mouse lung. The left lungs of C57BL/6 mice were irradiated at a high dose of 100 Gy. The histology of the lungs and spleen showed evidences of alveolar inflammation and congestion at 2 weeks after X-ray treatment. Also, prominent increase in cells expressing the cell surface markers, GrCD11bF4/80 and Ly6C Ly6G were observed 2 weeks after X-ray treatment (100 Gy). Gr1CD11bF4/80 cell depletion by clodronate treatment reversed the histological effects and also failed to recruit GrCD11b cells or F4/80 cells caused by irradiation. The origin of recruited Gr1CD11b cells was found to be a mixed resident and recruited phenotype.
- Subjects
INFLAMMATION; CD11 antigen; BONE marrow; SPLEEN; MORTALITY; IMMUNE system; IONIZING radiation
- Publication
Inflammation, 2015, Vol 38, Issue 2, p465
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-014-9952-8