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- Title
The Red Color of Life Transformed – Synthetic Advances and Emerging Applications of Protoporphyrin IX in Chemical Biology.
- Authors
Sitte, Elisabeth; Senge, Mathias O.
- Abstract
Protoporphyrin IX (PPIX) is the porphyrin scaffold of heme b, a ubiquitous prosthetic group of proteins responsible for oxygen binding (hemoglobin, myoglobin), electron transfer (cytochrome c) and catalysis (cytochrome P450, catalases, peroxidases). PPIX and its metallated derivatives frequently find application as therapeutic agents, imaging tools, catalysts, sensors and in light harvesting. The vast toolkit of accessible porphyrin functionalization reactions enables easy synthetic modification of PPIX to meet the requirements for its multiple uses. In the past few years, particular interest has arisen in exploiting the interaction of PPIX and its synthetic derivatives with biomolecules such as DNA and heme‐binding proteins to evolve molecular devices with new functions as well as to uncover potential therapeutic toeholds. This review strives to shine a light on the most recent developments in the synthetic chemistry of PPIX and its uses in selected fields of chemical biology.
- Subjects
CHEMICAL biology; CYTOCHROME c; MYOGLOBIN; CYTOCHROME P-450; CHARGE exchange; CATALYSIS; CHEMISTRY
- Publication
European Journal of Organic Chemistry, 2020, Vol 2020, Issue 22, p3171
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202000074