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- Title
Acylative Coupling of Amine and Indole Using Chloroform as a Carbonyl Group.
- Authors
Nishida, Yuika; Takeda, Norihiko; Matsuno, Kenji; Miyata, Okiko; Ueda, Masafumi
- Abstract
Chloroform‐mediated acylative coupling of amines with indoles has been developed. When indoles and amines in chloroform were treated with dimethylzinc in the presence of air, the three‐component aminocarbonylation reaction proceeded via in‐situ generation of phosgene from chloroform and O2 to provide indole‐3‐carboxamides in a single operation. Application to the synthesis of biologically active compounds and intramolecular acylation are also described.
- Subjects
ACYLATION; COUPLING reactions (Chemistry); INDOLE compounds; CHLOROFORM; CARBONYLATION
- Publication
European Journal of Organic Chemistry, 2018, Vol 2018, Issue 29, p3928
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201800571