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- Title
Interleukin-18 Is Associated With Protection Against Rhinovirus-Induced Colds and Asthma Exacerbations.
- Authors
Jackson, David J.; Glanville, Nicholas; Trujillo-Torralbo, Maria-Belen; Shamji, Betty W. H.; del-Rosario, Jerico; Mallia, Patrick; Edwards, Matthew J.; Walton, Ross P.; Edwards, Michael R.; Johnston, Sebastian L.
- Abstract
Rhinoviruses cause the common cold and exacerbations of asthma. Animal models of infection have identified a protective role for interleukin-18 (IL-18). Following experimental rhinovirus infection, we observed increased respiratory symptoms in healthy and asthmatic subjects with low nasal and bronchial IL-18 levels.
- Subjects
INTERLEUKIN-18; COMMON cold; RHINOVIRUSES; COMMON cold prevention; ASTHMA prevention
- Publication
Clinical Infectious Diseases, 2015, Vol 60, Issue 10, p1528
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/civ062