We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Potential Cost-Effectiveness of a Rotavirus Immunization Program in Rural China.
- Authors
Xuan-Yi Wang; Riewpaiboon, Arthorn; von Seidlein, Lorenz; Xing-Bao Chen; Kilgore, Paul E.; Jing-Chen Ma; Sun-Xiang Qi; Zhi-Yong Zhang; Zhi-Yong Hao; Ji-Chao Chen; Zhi-Yi Xu
- Abstract
Background. To assess the incidence and economic burden of rotavirus diarrhea and the potential cost-effectiveness of a rotavirus immunization program in rural Zhengding County in Hebei Province, China. Methods. Population-based surveillance was conducted during the peak season for diarrhea among children who were <5 years of age in Zhengding County from 14 October 2004 through 19 January 2005. The cost of illness was measured from the perspectives of both patient and society. A decision-analytic model was applied to the cost-effectiveness analysis using real data derived from surveillance and from a cost-of-illness study. Results. During the surveillance period, 500 episodes of diarrhea were registered. Of these 500 episodes, 125 (25%) occurred in patients who were positive for rotavirus. Of these 125 episodes, 63 (50%) occurred in patients who were hospitalized. The overall incidence rate of rotavirus infection was 61.4 cases per 1000 children per year during the 14-week epidemic season. For a Chinese cohort of 5000 newborns, a universal rotavirus immunization program would prevent 1764 cases of rotavirus diarrhea, averting 882 hospitalizations of patients ≤5 years of age. At 2004 prices, the net savings due to the immunization program would be US$14,112 from a societal perspective and US$34,751 from a patient perspective. Conclusion. Rotavirus was a leading cause of severe diarrhea among children <5 years of age and an economic burden for farmers in rural Zhengding County. Rotavirus vaccination should be considered as a potential cost-effective measure against rotavirus infection in China.
- Subjects
HEBEI Sheng (China); CHINA; ROTAVIRUSES; IMMUNIZATION; HOSPITAL care; IMMUNIZATION of children; COST effectiveness; DIARRHEA; EPIDEMICS
- Publication
Clinical Infectious Diseases, 2009, Vol 49, Issue 8, p1202
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/605632