We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Changes in the corpus callosum in women with late-stage bipolar disorder.
- Authors
Lavagnino, L.; Cao, B.; Mwangi, B.; Wu, M.‐J.; Sanches, M.; Zunta‐Soares, G. B.; Kapczinski, F.; Soares, J.
- Abstract
Objective This study investigated the differences in corpus callosum ( CC) volumes between women with early-stage and late-stage bipolar I ( BP I) disorder using the criteria previously described in the literature. Method We compared women with early- and late-stage BP I using criteria described in the Staging Systems Task Force Report of the International Society for Bipolar Disorders. We included 20 patients with early stage and 21 patients with late-stage BP I and a group of 25 healthy controls. Patients and controls underwent structural magnetic resonance imaging. Information on the clinical features of bipolar disorder was collected using a standardized questionnaire. Anatomical volumes of five regions of CC were compared between the three groups. Results Women with late-stage BP I disorder had reduced posterior CC volumes compared with early-stage bipolar I patients and controls ( F = 6.05; P = 0.004). The difference was significant after controlling for age, comorbidity with post-traumatic stress disorder, psychotic symptoms during mood episodes, and current use of medication. Conclusion The posterior CC was significantly decreased in volume in women with late-stage bipolar disorder. These findings suggest that CC may be an anatomical target of neuroprogression in the course of bipolar disorder in women.
- Subjects
BIPOLAR disorder; CORPUS callosum abnormalities; DISEASE progression; WOMEN'S health; MAGNETIC resonance imaging; PATIENTS
- Publication
Acta Psychiatrica Scandinavica, 2015, Vol 131, Issue 6, p458
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1111/acps.12397