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- Title
Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins.
- Authors
Myint, Phyoe Kyawe; Park, Eun Jeong; Gaowa, Arong; Kawamoto, Eiji; Shimaoka, Motomu
- Abstract
Exosomes represent an important subset of extracellular vesicles involved in inter-cellular communications in health and diseases. Exosomes secreted from cancer and immune cells travel to the specific tissues containing homing niches. The exosomes reaching the niches dynamically modify the gene expression and molecular architectures of the homing niche micro-environments. Cell adhesion molecule integrins regulate the tissue-specific homing patterns of not only cancer and immune cells, but also of the exosomes secreted from those cells. The exosome-mediated remodeling of the homing niches would affect immune lymphocyte migration and host defense, as well as cancer metastasis, thereby representing a potential therapeutic target.
- Subjects
EXOSOMES; CELL adhesion molecules; EXTRACELLULAR vesicles; CANCER cells; BREAST cancer; HOME remodeling
- Publication
Diagnostic Pathology, 2020, Vol 15, Issue 1, p1
- ISSN
1746-1596
- Publication type
Letter
- DOI
10.1186/s13000-020-00959-3